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Ifeoma, Udujih Hellen
- Hepatocellular Enzyme Activities and Protein Level Following Administration of Vitamins during Chloroquine Induced Hepatoxicity in Wistar Rats
Abstract Views :345 |
PDF Views:68
Authors
Nnodim Johnkennedy
1,
Ujowundu Cosmus Onyekachi
2,
Udujih Hellen Ifeoma
1,
Okorie Hope
1,
Nwobodo Emmanuel Ikechukwu
3,
Nwadike Constance Nnedimma
1
Affiliations
1 Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, NG
2 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, NG
3 ThankGod Medical Laboratories, Ihiala Anambra State, NG
1 Dept of medical laboratory science, faculty of health science, Imo State University, owerri, Imo State, NG
2 Department of Biochemistry, Federal University of Technology, Owerri, Imo State, NG
3 ThankGod Medical Laboratories, Ihiala Anambra State, NG
Source
Indian Journal of Innovations and Developments, Vol 1, No 4 (2012), Pagination: 299-302Abstract
Objective The effect of vitamins against chloroquine induced hepatoxicity was studied in wistar rats. Analysis of serum AST, ALT and ALP activities with those of total protein and albumin were carried out. Method: Single oral administration of chloroquine (970mg/kg body weight) caused significant increase in AST, ALT and ALP while protein and albumin concentration were reduced. However, simultaneous treatment of chloroquine with 200mg/kg body weight and 4.3 mg/kg of vitamin C and E respectively were administered for 14days. Results: The levels serum AST, ALT and ALP were significantly decreased following the treatment with vitamin C and E. Conclusion: These observations suggest that administration of high dose of chloroquine can cause increase in serum hepatocellular enzymes activities, which is suggestive of liver necrosis which can be ameliorated to varying degrees by vitamins C and E. Hence, fruits rich in vitamin C and E are highly recommended in liver disorders.Keywords
Hepato-cellular Enzymes, Protein, Chloroquine, HepatoxicityFull Text
References
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- Alterations in some Biochemical Indices of Hepatic Function in Tuberculosis Patients on Antituberclosis Therapy
Abstract Views :546 |
PDF Views:277
Authors
Nnodim Johnkennedy
1,
Afolabi Emmanuel Abiodun
1,
Udujih Hellen Ifeoma
1,
Okorie Hope
1,
Nwobodo Emmanuel Ikechukwu
2,
Nwadike Constance Nnedimma
1
Affiliations
1 Department of medical laboratory science, faculty of health science, Imo State University Owerri, Imo State, NG
2 Thank god medical Laboratories Ihiala, Anambra State, NG
1 Department of medical laboratory science, faculty of health science, Imo State University Owerri, Imo State, NG
2 Thank god medical Laboratories Ihiala, Anambra State, NG
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 1 (2012), Pagination: 12-15Abstract
This study was to investigate the hepatic pathophysiology and biochemical changes during antituberclosis therapy. Among the intake 200 patients: 60 were on therapy, another 60 were not on therapy, while 80 were non tuberculosis patient. A comparative decrease in the level of total protein and albumin in tuberculosis patients were recorded while increase in Asparate Aminotransfarace (AST), Alanine Aminotransferace (ALT), and Alkaline Phosphatase (ALP) were observed in comparison with the control. On treatment with antituberclosis therapy, the hepatic involvements are transient.Keywords
Biochemical Indices, Hepatic Pathophysiology, Antituberculosis TherapyFull Text
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